Wednesday, June 21, 2017

A rare opportunity

I presented the Alliance's poster at AACR.
By Suzie Siegel
Someday all cancers will be rare.

So says Rick Pazdur, MD, director of the FDA's Oncology Center of Excellence. As physicians and scientists learn more about genetics, they are breaking down cancers into smaller and smaller categories that may respond to specific drugs.

Dr. Pazdur spoke this spring to a group of advocates who won scholarships to attend the annual meeting of the American Association for Cancer Research (AACR) in Washington, D.C. I was the only sarcoma advocate in the Scientist↔Survivor Program, but that’s not surprising, considering sarcoma represents only 1 percent of adult cancer cases.

Carcinomas – what most people call cancer – are named for where they occur in the body, such as breast cancer or colon cancer. Sarcomas are named for the cells in which they are thought to come from. But sarcoma subtypes are now being divided still further.

Histological classifications are now supplemented by molecular subclassifications, which strongly influence prognosis and guide treatment decisions. More than ever, sarcomas are regarded as a complex and fragmented collection of uncommon entities, altogether rare and often extremely rare,” Jean-Yves Blay, MD, PhD, director of the Centre Léon Bérard in Lyon, France, wrote in Future Medicine. An example is liposarcoma, which arises in fat cells. It has been separated into well-differentiated, dedifferentiated, myxoid and pleomorphic liposarcoma.

Results of the largest study of sarcoma genetics were published last year, with more data coming from the Garvan Institute in Sydney, Australia. It leads the International Sarcoma Kindred Study, which is looking at the genetics of more than 1,000 people.

We also await more results from The Cancer Genome Atlas, a project of the National Cancer Institute in Bethesda, Md. Anna Barker, PhD, chair of the AACR survivor program, helped conceive and develop TCGA when she was deputy director of the NCI.  She is now co-director of Complex Adaptive Systems and director of the National Biomarker Development Alliance at Arizona State University in Tempe.

At the recent American Society of Clinical Oncology (ASCO) meeting in Chicago, a study was presented on an experimental drug named larotrectinib that targets TRK gene fusions. Some sarcoma patients should benefit.
 
The clinical trial was done basket-style, enrolling patients with different types of cancer. Getting enough sarcoma patients for meaningful research takes time; I think we benefit from basket studies that include people with other cancers. In a sense, many clinical trials in sarcoma have been basket studies because they enrolled people with different sarcoma subtypes.

Dr. Rick Pazdur
Companies need clinical trials to get their drugs approved. But Dr. Pazdur believes: “Clinical trials are here to serve the patient. Patients are not here to serve clinical trials.”

The FDA used to require companies prove that their drugs would help patients live longer. This can be hard to measure, in part because some patients have very advanced cancer by the time they go on a clinical trial. The FDA now approves some drugs if patients can go longer without their cancer progressing than they could on a standard drug. This change allowed trabectedin (Yondelis) to be approved for liposarcoma and leiomyosarcoma, for example.

I hope the FDA will use similar criteria to approve aldoxorubicin, which I wrote about in 2014.

Dr. Pazdur wants to expand access to clinical trials for patients who might not qualify because of how advanced their cancer is. He has suggested other innovations here and here. But he said he can do only so much because drug companies pay for almost all clinical trials. They control eligibility requirements, except where safety and a few other issues are concerned.

His desire to expand access stops at the “Right to Try” laws, which allow people with terminal illnesses to take unapproved drugs outside of trials. He said these laws directly contradict the Food, Drug and Cosmetic Act, which requires the FDA to oversee drug safety.

Trials are much more likely to be done in North America, Europe and Asia than in South America or Africa. That needs to be rectified, Dr. Pazdur said, to see if different populations respond differently to new drugs.

The AACR meeting drew 22,850 people from 60 countries, said CEO Margaret Foti, MD, PhD. She has spent 35 years with the organization and sees a much greater emphasis on cancer prevention.

Sarcoma researchers have been active in the AACR since its founding 110 years ago. The founders included Dr. William Coley, considered the father of immunotherapy, and Dr. James Ewing,  AACR’s first president. Dr. Ewing discovered the bone sarcoma that bears his name.  

George Demetri, MD, director of the Center for Sarcoma and Bone Oncology at Dana-Farber Cancer Institute in Boston, is on AACR’s current board. He decries cuts in federal funding for cancer research. “I do not believe for one second this is what the public wants.” 

Dr. Drew Pardoll
Recent gains in immunotherapy show the importance of investing in science even when the payoff isn’t immediate, said Drew Pardoll, MD, PhD, director of the Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University in Baltimore. He has been working in the field more than 30 years.

“Cancer genetics has married immunotherapy,” said Dr. Pardoll, discussing how pembrolizumab (Keytruda) works in people with DNA mismatch-repair deficiency (MMR), which causes microsatellite instability (MSI).

After approving Keytruda last month for this genetic defect, the FDA noted: “This is the first time the agency has approved a cancer treatment based on a common biomarker.”

Stefanie Joho
The evidence for supporting immunotherapy stood by Dr. Pardoll’s side: Stefanie Joho of Philadelphia, whose colon cancer disappeared after she joined a clinical trial for Keytruda. She recalled when she was inoperable: “The doctors say there’s nothing they can do. There’s no more hope. I’m ready to give up. I basically feel dead.”

Then her sister found the study at Hopkins. “The public has a misconception of clinical trials. I did, too. I was under the impression they were the last resort. I’d just be a guinea pig. But right now, you could be getting the most precise treatment for your specific kind of cancer.

“How do you go through an experience like this and not want to advocate, not just for other patients, but for cancer research?”

Suzie Siegel, a 15-year survivor of leiomyosarcoma, is a former board member of the Sarcoma Alliance. 

39 comments:

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Clara James said...

GREAT LOVE SPELL CASTER PRIEST WISDOM THAT HELP ME SAVE MY RELATIONSHIP.TEXT OR ADD HIM UP ON WHATSAPP: +2348124644470

 My name is CLARA JAMES .i want to give thanks to PRIEST WISDOM for bringing back my ex husband.No one could have ever made me believe that the letter I’m about to write would actually one day be written. I was the world’s biggest skeptic. I never believed in magic spells or anything like this, but I was told by a reliable source (a very close co-worker) that Trust is a very dedicated, gifted, and talented person,It was one of the best things I have ever done. My love life was in shambles; I had been through two divorces and was on the brink of a third. I just couldn't face another divorce, and I wanted to try harder to make our relationship work, but my husband didn’t seem to care. and he brake up with me again.I was confuse and do not no what to do again,rather them to get in contact with PRIEST WISDOM . He did a love spell that make my husband come back to me. we are now very much happy with our self. PRIEST WISDOM make him to realize how much we love and need each other.This man is for REAL and for good.he can also help you to fix your broken relationship. I had my husband back! It was like a miracle! He suddenly wanted to go to marriage counseling, and we’re doing very, very well,in our love life.contact email Supernaturalspell1@gmail.com or his web page   https://supernaturalspell21.blogspot.com/     text or add him up on whatsApp at: +2348124644470 /.........

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neme amber said...

I got my already programmed and blanked ATM card to withdraw the maximum of $1,000 daily for a maximum of 20 days. I am so happy about this because i got mine last week and I have used it to get $20,000. Mike Fisher Hackers is giving out the card just to help the poor and needy though it is illegal but it is something nice and he is not like other scam pretending to have the blank ATM cards. And no one gets caught when using the card. get yours from Mike Fisher Hackers today! *email cyberhackingcompany@gmail.com

Sophia Mason said...

GET RICH WITH BLANK ATM CARD ... Whatsapp: +18033921735

I want to testify about Dark Web blank atm cards which can withdraw money from any atm machines around the world. I was very poor before and have no job. I saw so many testimony about how Dark Web hackers send them the atm blank card and use it to collect money in any atm machine and become rich. ( darkwebblankatmcard@gmail.com ) I email them also and they sent me the blank atm card. I have use it to get 90,000 dollars. withdraw the maximum of 5,000 USD daily. Dark Web is giving out the card just to help the poor. Hack and take money directly from any atm machine vault with the use of atm programmed card which runs in automatic mode.

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amos said...

Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.odoma the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.odoma write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.odoma instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drodomasolutionhome20@gmail.com or you can also WhatsApp him +2348100649947. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

WENDY CUTRONA said...

Hello am looking few years that some guys comes into the market they called themselves hacker, carder or spammer they rip the peoples with different ways and it’s a badly impact to real hacker now situation is that peoples doesn’t believe that real hackers and carder scammer exists. Anyone want to make deal with me any type am available but first I‘ll show the proof that am real then make a deal like Available Services ..Credit cards, Blank ATM cards Wire Bank Transfer all over the world ..Western Union Transfer all over the world ..Credit Cards (USA, UK, AUS, CAN, NZ) ..School Grade upgrade / remove Records ..Spamming Tool ..keyloggers / rats ..Social Media recovery .. Teaching Hacking / spamming / carding (1/2 hours course) discount for re-seller Contact: 24/7    specially programmed ATM cards that can be used to hack any ATM machine, this ATM cards can be used to withdraw at the ATM or swipe, stores and outlets. We sell this cards to all our customers and interested buyers worldwide, the cards has a daily withdrawal limit of $5000 in ATM and up to $50,000 spending limit in stores. and also if you in need of any other cyber hacking services, we are here for you at any time any day.     Whatsapp: +13053303282    EMAIL:   Creditcards.atm@gmail.com GET YOUR CREDIT CARDS AT LOW COST

amos said...

Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.odoma the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.odoma write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.odoma instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drodomasolutionhome20@gmail.com or you can also WhatsApp him +2348100649947. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

amos said...

Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.odoma the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.odoma write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.odoma instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drodomasolutionhome20@gmail.com or you can also WhatsApp him +2348100649947. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

ben said...

I got this already programmed ATM cards called the blank ATM card which can withdraw over $10,000 from any ATM machine. I read about it and I got mine from a great hacker which I melt online I thought it's never going to work but I just have to see where it will lead me to and I ordered for the card and I got the card just as he said and I wasn't still convinced not until I withdraw with this card and I have withdraw a lot with this card and it is legit and real you can get you and see get in touch with him with his email

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ELSA said...

Have you heard about programmed ATM card? I have my ATM card, already programmed BY Mr Perry Thomas. It is illegal but nice to have one not like other scammers pretending to have the ATM card. The ATM card can be used to withdraw cash at any ATM or swipe, stores and online purchase. Get yours today by sending an email to perrythomas827@gmail.com .... THIS IS 100% REAL. I AM A BENEFICIARY OF THESE. HACKERS EMAIL: perrythomas827@gmail.com

BENITO FAUSTO said...

INSTEAD OF GETTING A LOAN, CHECK OUT THE BLANK ATM CARD IN LESS THAN 24hours {oscarwhitehackersworld@gmail.com}


I want to testify about OSCAR WHITE blank ATM cards which can withdraw money from any ATM machines around the world. I was very poor before and have no hope then I saw so many testimony about how OSCAR WHITE send them the blank ATM card and i use it to collect money in any ATM machine and become rich. I also email him and he sent me the blank card. I have use it to get $100,000 dollars. withdraw the maximum of $5,000 daily.OSCAR WHITE is giving out the card just to help the poor. Hack and take money directly from any ATM Machine Vault with the use of ATM Programmed Card which runs in automatic mode. email Him on how to get it now via: oscarwhitehackersworld@gmail.com or whats-app +1(323)-362-2310

Sharon Wayne said...

I want to thank Dr Emu a very powerful spell caster who help me to bring my husband back to me, few month ago i have a serious problem with my husband, to the extend that he left the house, and he started dating another woman and he stayed with the woman, i tried all i can to bring him back, but all my effort was useless until the day my friend came to my house and i told her every thing that had happened between me and my husband, then she told me of a powerful spell caster who help her when she was in the same problem I then contact Dr Emu and told him every thing and he told me not to worry my self again that my husband will come back to me after he has cast a spell on him, i thought it was a joke, after he had finish casting the spell, he told me that he had just finish casting the spell, to my greatest surprise within 48 hours, my husband really came back begging me to forgive him, if you need his help you can contact him with via email: Emutemple@gmail.com or add him up on his whatsapp +2347012841542 is willing to help any body that need his help.

Asore Corp said...

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All rights reserved.

Conley Tiffany said...

Dr Itua cures my HIV, I have been an ARV Consumption for 10 years. I have been in pain until I came across Dr Itua on a blog site. I emailed him about my details of my HIV and my location I explained everything to him and he told me that there is nothing to be scared of that he will cure me, he gave me guarantee, He asks me to pay for items fees so when I'm cured I will show gratitude I did and giving testimony of his healing herbs is what I'm going to do for the rest of you out there having HIV and other disease can see the good work of Dr Itua. I received his herbal medicine through EMS Courier service who delivered to my post office within 5 working days. Dr Itua is an honest man and I appreciate him for his good work. My GrandMa called him to appreciate him and the rest of my friends did too, Is a joy to me that I'm free of taking Pills and having that fat belle is a nightmare.you will understand what I'm talking about if you have the same problem I was having then not now though. I'm free and healthy Big Thanks To Dr Itua Herbal Center. I have his calendar too that he recently sent me, He Cures all kind disease Like, Cancer,Weak Erection, Wart Remover,Hpv, Herpes,Alzheimer’s disease,Bechet’s disease,Crohn’s disease,Cushing’s disease, Heart failure, Multiple Sclerosis, Hypertension,Fibromyalgia,Hiv, Hepatitis B, Liver/Kidney Inflammatory, Epilepsy,Blood Cancer, Prostate Cancer, Colo-Rectal Cancer, Brain Cancer, Lung Cancer, Infertility,Parkinson's disease, Lung Cancer, Breast Cancer, Colo-Rectal Cancer, Blood Cancer, Prostate Cancer, Epilepsy disease, small-round-cell tumor Diabetes,Celiac disease, Ataxia, Arthritis, measles, tetanus, whooping cough, tuberculosis, polio, Seizures,Alzheimer's disease,Adrenocortical carcinoma, Asthma, Allergic diseases.Hiv/Aids,Herpe ,Copd, Glaucoma, Cataracts,Macular degeneration,Cardiovascular disease,Lung disease, Enlarged prostate, Alzheimer disease,Dementia,Fibroid,Diabetes,Dercum,Copd,and also Bring back Ex Lover Back. Here his Contact. drituaherbalcenter@gmail.com Or Whats_app Number +2348149277967

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harry konig said...

I was searching for a loan to sort out my bills & debts, then I saw comments about Blank ATM Credit Cards that can be hacked to withdraw money from any ATM machines around you . I doubted this but decided to give it a try by contacting { officialblankatmservice@gmail.com} they responded with their guidelines on how the card works. I was assured that the card can withdraw $5,000 instant per day & was credited with $50,000,000.00 so i requested for one & paid the delivery fee to obtain the card, after 24 hours later, i was shock to see the UPS agent in my resident with a parcel {card} i signed and went back inside to pick up my car key and drove to a nearest ATM machine to confirmed if the card really work to my greatest surprise it did.. This is no doubt because I have the card & have made use of the card. These hackers are UK based hackers set out to help people with financial freedom!! Contact them via email: officialblankatmservice@gmail.com or WhatsApp +447937001817 if you want to get rich.

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Have you guys heard of blank ATM card? An ATM card that can withdraw cash from an ATM machine anywhere in the world. Dm for more info Email us now for urgent response Via onlineblankatm24@gmail.com

perez turner said...


GET RICH WITH THE USE OF BLANK ATM CARD FROM
(besthackersworld58@gmail.com)
Has anyone here heard about blank ATM card? An ATM card that allows you to withdraw cash from any Atm machine in the world. No name required, no address required and no bank account required. The Atm card is already programmed to dispense cash from any Atm machine worldwide. I heard about this Atm card online but at first i didn't pay attention to it because everything seems too good to be true, but i was convinced & shocked when my friend at my place of work got the card from guarantee Atm card vendor. We both went to the ATM machine center and confirmed it really works, without delay i gave it a go. Ever since then I’ve been withdrawing $1,500 to $5000 daily from the blank ATM card & this card has really changed my life financially. I just bought an expensive car and am planning to get a house. For those interested in making quick money should contact them on: Email address : besthackersworld58@gmail.com or WhatsApp him on +1(323)-723-2568

ANITA DELPH said...

HOW I GOT MY HUSBAND BACK WITH THE HELP OF DR LARRY CONTACT ON WHATSAPP NUMBER +1(424)-261-8520

I want to say thank you to Dr Larry for the good thing he has done for me though I am not sure if this is the best forum to show my joy and happiness for what he has done for me but I can't hide my happiness and my Joy so I have to share it with the world.
My marriage crashed about two years ago and I tried all I could within my powers to restore it but to no avail. I saw different posts and testimonies about the good things Dr Larry has been doing so I decided to give it a try. Though he is always a busy man, when he responded back to my email, he gave me 48 hours for my marriage to be restored and just like he said my marriage was restored, since then I am happy and I am living happily in my marriage. I am so grateful to Dr Larry you can always contact him here: assurancesolutionhome@gmail. com or u can WhatsApp him via +1(424)-261-8520 website http://assurancesolutioncenter.website2.me/

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